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Senior Group Leader —Cell Thera...

ID:123216386 分享到微信

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  • 五险一金
  • 免费班车
  • 员工旅游
  • 餐饮补贴
  • 年终奖金
  • 定期体检
  • 弹性工作
  • 补充医疗保险
职位信息
  • 启动日期:2020-07-12
  • 招聘部门:其他
  • 汇报对象:无
  • 下属人数:无
  • 职位描述:
  • 职位描述

    We are seeking an experienced PhD level scientist to join in a multidisciplinary team doing cutting-edge sciences in Cell Therapy at BioDuro (Shanghai site). The successful candidate must have broad expertise in cellular immunology, and is familiar with the latest technologies in immune cell engineering, including development of allogeneic CAR T cells. The candidate should have excellent written and oral communication skills, and the ability to work independently and efficiently in a fast-paced and customer-oriented environment.
    岗位职责

    Responsibilities:
    ? Develop molecular biology techniques including new multi-fragment plasmid assembly technologies
    ? Implement multiplexed gene editing strategies for cell-based therapies and allogeneic products
    ? Engineer mammalian cells especially immune cells such as T cells, and stem cells such as HSC and iPSCs with genome editing tools such as CRISPR/Cas and perform downstream molecular and cellular analysis including next generation sequencing (NGS)
    ? Culture mammalian primary cells and cells lines, and introduce plasmid DNA, mRNA, gRNA and Cas9 RNP by appropriate methods, including cationic lipid-based transfection and electroporation
    ? Conduct research involving standard molecular biology techniques including DNA extraction and analysis, qPCR, and various plate-based assays
    ? Apply basic biochemical and immunological techniques, including protein extraction, protein gel electrophoresis, conventional and capillary western blotting, ELISA, cytokine assays and flow cytometry
    ? Lead a group of scientists and work across other platform technology and therapeutic groups to achieve desired goals
    任职要求

    Qualifications
    Education and Work Experience Requirement:
    ? PhD in immunology, cell biology, oncology or related fields and at least 4 years of work experience, preferably in a Biotech/Pharmaceutical/CRO setting. PhD with highly relevant postdoctoral experience will also be considered.
    Knowledge and Skills Requirement:
    ? Detailed knowledge of cellular immunology principles, technologies, and experimental techniques (cell culture, in vitro cellular assays, flow cytometry, and other standard molecular and cell biology techniques)
    ? Strong knowledge in the field of gene editing and gene therapy.
    ? Proficiency with mammalian cell culture techniques including maintenance of cell lines, transfection, cell counting, and standard cellular assays
    ? Experience with flow cytometry and cell sorting for mammalian cells is desirable
    ? Experience with lentiviral production and transduction
    ? Working knowledge of molecular and cellular research techniques, including RNA/DNA extraction, PCR, ddPCR, qPCR, western blotting and ELISA
    ? Working knowledge of, and direct experience with, CRISPR/Cas gene editing in primary mammalian cells
    ? Demonstrated ability to collaborate with peers and effectively work in a team-oriented environment
    ? Strong capability in designing and planning experiments and to meet project goals and timelines.
    ? Strong leadership skills to guide team member to perform their responsibilities.

职位要求
  • 年龄要求:不限

    工作年限:5-7年

  • 学历要求:博士及以上

    专业要求:生物医学工程

  • 是否统招:统招

    语言要求:英语

企业介绍

关于BioDuro

保诺科技是一家领先的生命科学研发公司,专业为生物制药客户提供从靶标识别到III期的一体化药物研发服务。
保诺北京位于中关村生命科学园,是中国总部,自2006年开始投入运营。目前拥有近500名员工,专业服务包含药物化学,合成化学,化学工艺,小分子制剂,化学分析以及单克隆抗体研发。
保诺上海创新药物研发中心位于外高桥自贸区,近500名员工,致力于一体化药物发现项目,专业服务包含药物化学,药研生物,体外药理学,药代动力学,设有ADME、生物分析、体外测定及体内药代动力学实验室,并拥有一个1,800平方米获得AAALAC认证的动物房,拥有17台一流的串级质谱仪和高分辨串级质谱仪。上海的肿瘤学团队已经在上海建立了世界***个3D肿瘤微环境筛选平台。此外,在上海还建有世界领先水平的针对实体瘤的CAR-T研发实验室。
保诺无锡将于2020年起投入使用,占地面积30000平方米,业务包括,药物化学,药理学,发现生物学,药代动力学,药效学,大分子药物研发,制剂学,化学工艺开发等业务, 拥有hTME-3DX, FBDD, DEL, 抗体研发,细胞治疗等国际先进的技术平台.

上海润诺生物科技有限公司

  • 外资(欧美)
  • 150-500人
  • 制药/医疗
  • 上海市外高桥富特北路233号 地图